Energy balance and the sphingosine-1-phosphate/ceramide axis

Peer reviewedPublisher PD

Systematic Review of the Addition of Hip Strengthening Exercises for Adults with Patellofemoral Pain Syndrome

Patellofemoral Pain Syndrome (PFPS) is a common musculoskeletal disorder typically occurring in physically active people aged 40 years and younger, causing pain, functional deficits and lower limb weakness. Traditional treatment has been aimed at strengthening the knee, however recent research suggests the muscles around the hip also play an important role in the development and continuity of Patellofemoral Pain Syndrome. Purpose: To investigate the effectiveness of the addition of hip strengthening exercises to standard physiotherapy treatment (knee strengthening and stretching exercises) on reducing pain, and enhancing strength and function when compared to standard physiotherapy treatment alone in adults with Patellofemoral Pain Syndrome. Method: A systematic search of Cochrane, CINAHL, Embase, MEDLINE®, PEDro and SportDiscus was conducted. Studies of participants aged 18 to 44, diagnosed with Patellofemoral Pain Syndrome by a healthcare practitioner, or reporting peripatellar or retropatellar pain with common functional tasks, were included. A critical appraisal, using the Critical Appraisal Skills Program for Randomised Controlled Trials (CASP) was used to assess methodological quality. Results: Five randomised controlled trials of varying methodological quality met the inclusion criteria. The participants in these studies were aged between 18 to 40 years of age. The duration of the intervention ranged from four to six weeks consisting of 12 to 30 supervised exercise sessions. Studies used varying outcome measures for each of the three outcomes. Overall, the studies demonstrated that the addition of hip strengthening exercises to standard physiotherapy care consistently improved pain and function, but the impact on strength was variable. Conclusion: Previously, only a small number of studies have looked at the addition of hip exercises to standard physiotherapy care for treatment of Patellofemoral Pain Syndrome. While there is a growing body of evidence for the efficacy of hip strengthening exercises for Patellofemoral Pain Syndrome, this is constrained by bias towards female participants, lack of true controls in most studies, and low methodological quality of studies overall. Hip exercises added to standard physiotherapy care shows potential as a treatment method for improving outcomes of pain and function in adults with Patellofemoral Pain Syndrome

The effects of graded levels of calorie restriction : IV. Non-linear change in behavioural phenotype of mice in response to short-term calorie restriction

We would like to acknowledge the BSU staff for their invaluable help with caring for the animals. The work was supported by the UK Biotechnology and Biological Sciences Research Council BBSRC (BB/G009953/1 and BB/J020028/1).Peer reviewedPublisher PD

The effects of graded levels of calorie restriction : III. Impact of short term calorie and protein restriction on mean daily body temperature and torpor use in the C57BL/6 mouse

GRANT SUPPORT This work was supported by BBSRC BB009953/1 awarded to JRS and SEM. PK and CD were funded by the Erasmus exchange programme. JRS, SEM, DD, CG, LC, JJDH, YW, DELP, DL and AD are members of the BBSRC China Partnership Award, BB/J020028/1.Peer reviewedPublisher PD

The effects of graded levels of calorie restriction : XI. Evaluation of the main hypotheses underpinning the life extension effects of CR using the hepatic transcriptome

We would like to acknowledge the BSU staff for their invaluable help with caring for the animals.Peer reviewedPublisher PD

The effects of graded levels of calorie restriction : V. Impact of short term calorie and protein restriction on physical activity in the C57BL/6 mouse

Peer reviewedPublisher PD

The effects of graded levels of calorie restriction : XX. impact of long term graded calorie restriction on survival and body mass dynamics in male C57BL/6J mice

The funding was raised by J.R.S. (Biotechnology and Biological Sciences Research Council, grant/award number: BB/G009953/1).Peer reviewedPublisher PD

The effects of graded levels of calorie restriction : II. Impact of short term calorie and protein restriction on circulating hormone levels, glucose homeostasis and oxidative stress in male C57BL/6 mice

This work was supported by BBSRC BB009953/1 awarded to JRS and SEM. PK and CD were funded by the Erasmus exchange programme. JRS, SEM, DD, CG, LC, JJDH, YW, DELP, DL and AD are members of the BBSRC China Partnership Award, BB/J020028/1.Peer reviewedPublisher PD

The effects of graded levels of calorie restriction : VIII. impact of short term calorie and protein restriction on basal metabolic rate in the C57BL/6 mouse

We are grateful to the animal house staff for looking after the animals. The work was supported by the UK Biotechnology and Biological Sciences Research Council BBSRC (grants BB/G009953/1 and BB/J020028/1) to JRS and SEM. DD was supported by a studentship from the Centre for Genome Enabled Biology and Medicine, Aberdeen, UK, and CG was supported by a BBSRC EastBio studentship. Joint meetings were funded by a BBSRC China partnering award (BB/JO20028/1).Peer reviewedPublisher PD

Association of Aerobic Fitness and Metabolic Syndrome in Male Firefighters

Metabolic syndrome has been shown in numerous studies to be related to a higher incidence of coronary artery disease. A study by Jurca and coworkers (Med. Sci. Sports Exerc 36(8):1301-1307, 2004) found a relationship between aerobic fitness and the prevalence of metabolic syndrome in a group of men enrolled in the Aerobics Center Longitudinal Study (ACLS). In addition, recent work in our lab (Int J Exerc Sci 2(1): S43, 2009) has supported these findings. However, research exploring this relationship is still lacking in male firefighters, whose leading cause of line-of-duty deaths is heart attacks. Purpose: To further evaluate the association of metabolic syndrome and aerobic fitness in male fire fighters. Methods: As part of an annual physical exam, 210 male fire fighters (average age = 36) underwent evaluation of risk factors associated with metabolic syndrome as defined by NCEP III. These include the presence of three or more of the following: Waist Circumference \u3e 40 , HDL Cholesterol \u3c 40 mg/dL, Triglycerides \u3e 150 mg/dL, Blood Glucose \u3e 110 mg/dL, and Resting Blood Pressure \u3e 130/85 mm Hg. Aerobic Fitness was determined by estimating VO2max from time on treadmill during a Bruce protocol. Results: The subjects were ranked and divided into quartiles based on VO2max. All data were analyzed using a Chi Square test (p \u3c 0.05). Prevalence of metabolic syndrome increased significantly across quartiles as aerobic fitness declined. Conclusion: These data suggest that as aerobic fitness improves, the likelihood of male firefighters having metabolic syndrome decreases